Chemical synthesis and characterization of two a4/7-conotoxins
نویسندگان
چکیده
Can Peng1,2, Weihua Chen1, Tanya Sanders3, Geoffrey Chew3, Jing Liu3, Edward Hawrot3, and Chengwu Chi1,4* Institute of Protein Research, College of Life Sciences and Technology, Tongji University, Shanghai 200092, China Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai 200240, China Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China *Correspondence address. Tel: þ86-21-54921165; E-mail: [email protected]
منابع مشابه
Chemical synthesis and characterization of two α4/7-conotoxins.
α-Conotoxins are small disulfide-constrained peptides that act as potent and selective antagonists on specific subtypes of nicotinic acetylcholine receptors (nAChRs). We previously cloned two α-conotoxins, Mr1.1 from the molluscivorous Conus marmoreus and Lp1.4 from the vermivorous Conus leopardus. Both of them have the typical 4/7-type framework of the subfamily of α-conotoxins that act on neu...
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